Article
Coessentiality and cofunctionality: a network approach to learning genetic vulnerabilities from cancer cell line fitness screens
2017-05-04
Abstract excerpt
Genetic interaction networks are a powerful approach for functional genomics, and the synthetic lethal interactions that comprise these networks offer a compelling strategy for identifying candidate cancer targets. As the number of published shRNA and CRISPR perturbation screens in cancer cell lines expands, there is an opportunity for integrative analysis that goes further than pairwise synthetic lethality and di...
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Identifiers and source
- Literature Corpus work
- 8f47f24b-8000-56b0-bed0-a9ef16caa556
- DOI
- 10.1101/134346