Article

Coessential Genetic Networks Reveal the Organization and Constituents of a Dynamic Cellular Stress Response

2019-11-20

Abstract excerpt

<h4>Summary</h4> The interrelated programs essential for cellular fitness in the face of stress are critical to understanding tumorigenesis, neurodegeneration, and aging. However, modelling the combinatorial landscape of stresses experienced by diseased cells is challenging, leaving functional relationships within the global stress response network incompletely understood. Here, we leverage genome-scale fitness s...

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Literature Corpus work: e7b0eb2f-3f00-5a6e-ba36-6ef50eb42897
DOI: 10.1101/847996

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