Article

Multiomic Evidence for a Unified Model of Alzheimer’s Disease Etiology Linking Microglial Flux Capacity and Astrocyte-Neuron Metabolic Breakdown

2024-07-24

Abstract excerpt

Age and APOE genotype are the strongest known risk factors for late-onset Alzheimer’s disease (AD), but the mechanisms linking them to neuronal loss remain incompletely defined. Using multiomic data from the Alzheimer’s Disease Neuroimaging Initiative (ADNI), we propose a unified hypothesis in which two interdependent failure modes—saturation of microglial lipid flux capacity and disruption of the astrocyte–neuron...

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Literature Corpus work: 536d63b5-e668-5f0e-a169-57187097a06f
DOI: 10.1101/2024.07.23.604835

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