Article

Carbonyl stress primes the metastable aging brain for Alzheimer’s disease

2026-07-28

Abstract excerpt

Alzheimer’s disease (AD) is defined by amyloid-β (Aβ) plaques and tau tangles, yet the inflammation that comes with it is only partly localized where those lesions accumulate. Using spatial transcriptomics on 16 human hippocampal sections containing adjacent cortex, we found that plaques concentrated in grey matter, especially cortex. In contrast, the strongest inflammatory response occupied white matter and incre...

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Literature Corpus work: 7fc972a4-1750-53eb-b288-1f154254b3ef
DOI: 10.64898/2026.07.24.740487

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