Article

Amyloid β Induces Lipid Droplet-Mediated Microglial Dysfunction in Alzheimer’s Disease

2023-06-06

Abstract excerpt

<h4>Summary</h4> Several microglia-expressed genes have emerged as top risk variants for Alzheimer’s disease (AD). Impaired microglial phagocytosis is one of the main proposed outcomes by which these AD-risk genes may contribute to neurodegeneration, but the mechanisms translating genetic association to cellular dysfunction remain unknown. Here we show that microglia form lipid droplets (LDs) upon exposure to amy...

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Literature Corpus work: 22f444da-f965-5a54-b183-8224dda97fe2
DOI: 10.1101/2023.06.04.543525

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