Article

Cell type-specific master metabolic regulators of Alzheimer’s disease

2025-07-17

Abstract excerpt

<h4>ABSTRACT</h4> Alzheimer’s disease (AD) exhibits metabolic heterogeneity; yet, the consequences on metabolic dynamics in a cell-type-specific manner and the underlying metabolite-sensor network basis remain unclear. Here, we show that neurons exhibit a striking decrease in energy and lipid-related metabolic activity, contrasted by an increase in microglial metabolism associated with neuroinflammation. To ident...

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Literature Corpus work: 77819978-6d9c-576f-b861-462c655ca2f9
DOI: 10.1101/2025.07.11.664443

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