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Microglial States Are Susceptible to Senescence and Cholesterol Dysregulation in Alzheimer's Disease

11 Aug 2025

Abstract excerpt

Cellular senescence is a major contributor to aging-related degenerative diseases, including Alzheimer's disease (AD), but much less is known about the key cell types and pathways driving senescence mechanisms in the brain. We hypothesized that dysregulated cholesterol metabolism is central to cellular senescence in AD. We analyzed single-cell RNA-seq data from the ROSMAP and SEA-AD cohorts to uncover cell...

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PMID: 40790613
DOI: 10.1111/acel.70189

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