Article

APOE ε4 genotype defines divergent trajectories of microglial metabolic stress across Alzheimer's disease progression: single-nucleus transcriptomic evidence linking lipid dysregulation to cognitive decline

2026-04-27

Abstract excerpt

<title>Abstract</title> <p> <bold>Background:</bold> Microglial activation is increasingly implicated in Alzheimer's disease (AD) pathophysiology, yet the cell-type specificity of glial metabolic stress responses and their relationship to tau pathology and cognitive decline remain poorly characterized. We examined whether a lipid-metabolic gene expression signature, the Metabolic Stress Score (MSS), differed ac...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: 08869ea5-3f25-5530-8650-9ccdb034d0d5
DOI: 10.21203/rs.3.rs-9401612/v1

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

APOE ε4 genotype defines divergent trajectories of microglial metabolic stress across Alzheimer's disease progression: single-nucleus transcriptomic evidence linking lipid dysregulation to cognitive declineDOI 10.21203/rs.3.rs-9401612/v1Read

APOE4 Drives Uniquely Dysfunctional Human Microglial States in Alzheimer’s DiseaseSemantic proximity Read

Transcriptional landscape of human microglia reveals robust gene expression signatures that implicates age, sex and APOE-related immunometabolic pathway perturbationsSemantic proximity Read

Multiomic Evidence for a Unified Model of Alzheimer’s Disease Etiology Linking Microglial Flux Capacity and Astrocyte-Neuron Metabolic BreakdownSemantic proximity Read

Metabolic Transcriptional Heterogeneity in Human Microglia Across the Alzheimer's Disease Pathological Continuum: A Donor-Aware Analysis of the SEA-AD AtlasSemantic proximity Read

Transcriptional landscape of human microglia reveals robust gene expression signatures that implicates age, sex and <i>APOE</i> -related immunometabolic pathway perturbationsSemantic proximity Read

Carbonyl stress primes the metastable aging brain for Alzheimer’s diseaseSemantic proximity Read

APOE4/4 is linked to damaging lipid droplets in Alzheimer’s microgliaSemantic proximity Read

Human microglia show unique transcriptional changes in Alzheimer’s diseaseSemantic proximity Read

Diverse human astrocyte and microglial transcriptional responses to Alzheimer’s pathologySemantic proximity Read

ApoE Lipidation State Directs Immunometabolic Reprogramming of Human MicrogliaSemantic proximity Read

High-Resolution Spatial Profiling of Microglia Reveals Proximity Associated Immunometabolic Reprogramming in Alzheimer’s DiseaseSemantic proximity Read

Diverse human astrocyte and microglial transcriptional responses to Alzheimer’s pathologySemantic proximity Read