Article

Tau spreading coordinates intercellular lipid flux enhancing neuronal resilience to lipid toxicity

2026-08-04

Abstract excerpt

The presence of intrinsically disordered proteins (IDPs) in the extracellular environment of the brain suggests that protein disorder may serve functions beyond those confined to the intracellular space. Tau, a prototypical IDP linked to tauopathies, a class of neurodegenerative diseases, is continuously released and spreads between cells in the brain, yet the biological significance of this extracellular phase re...

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Literature Corpus work: 9738029b-e3c1-500b-adff-19d12fb68287
DOI: 10.64898/2026.07.30.741734

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