Article

Microglia States are Susceptible to Senescence and Cholesterol Dysregulation in Alzheimer’s Disease

2024-11-19

Abstract excerpt

Cellular senescence is a major contributor to aging-related degenerative diseases, including Alzheimer’s disease (AD) but much less is known on the key cell types and pathways driving mechanisms of senescence in the brain. We hypothesized that dysregulated cholesterol metabolism is central to cellular senescence in AD. We analyzed whole transcriptomic data and utilized single-cell RNA seq integration techniques to...

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Literature Corpus work: c638f604-cecb-52c3-b7df-c508c17c9f4f
DOI: 10.1101/2024.11.18.624141

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