Article

TREM2 fuels the anabolic adaptation required for microglial resilience in Alzheimer’s disease

2026-03-27

Abstract excerpt

<title>Abstract</title> <p>The microglial response to Alzheimer’s disease (AD) pathology has canonically been defined by the transcriptional transition to a Disease-Associated Microglia (DAM) state. However, the specific metabolic programs required to fuel the high-demand functions of this reactive state, such as Aβ encapsulation and clearance, remain obscure. Here, we identify a TREM2-dependent anabolic adaptati...

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Literature Corpus work: 5efe9d4c-a959-55cd-a1c3-34b7950915a7
DOI: 10.21203/rs.3.rs-8896508/v1

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