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Systematic characterization of cell type-specific master metabolic regulators in Alzheimer's disease

2025-08-18

Abstract excerpt

<title>Abstract</title> <p>Alzheimer’s disease (AD) exhibits metabolic heterogeneity; yet, the consequences on metabolic dynamics in a cell-type-specific manner and the underlying metabolite-sensor network basis remain unclear. Here, we show that neurons exhibit a striking decrease in energy and lipid-related metabolic activity, contrasted by an increase in microglial metabolism associated with neuroinflammation....

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Literature Corpus work
d9333ba9-305b-5b4b-967c-70f777637281
DOI
10.21203/rs.3.rs-7207381/v1
Open publication

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Systematic characterization of cell type-specific master metabolic regulators in Alzheimer's diseaseDOI 10.21203/rs.3.rs-7207381/v1
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