Article

Single Cell-type Integrative Network Modeling Identified Novel Microglial-specific Targets for the Phagosome in Alzheimer’s disease

2020-06-10

Abstract excerpt

<h4>Summary</h4> Late-Onset Alzheimer’s Disease (LOAD) results from a complex pathological process influenced by genetic variation, aging and environment factors. Genetic susceptibility factors indicate that myeloid cells such as microglia play a significant role in the onset of LOAD. Here, we developed a computational systems biology approach to construct probabilistic causal and predictive network models of gen...

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Literature Corpus work: 37e1e91c-28d5-538d-92b5-0451877dc620
DOI: 10.1101/2020.06.09.143529

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