Article

Facilitation of hERG channels by blockers: a mechanism predicted to reduce lethal cardiac arrhythmias

2018-06-08

Abstract excerpt

Fatal cardiac arrhythmias are caused by some, but not all, drugs that inhibit the cardiac rapid delayed-rectifier current ( I Kr ) by blocking hERG channels. Here, we propose a novel mechanism that could make certain hERG blockers less proarrhythmic. Several drugs that block hERG channels, yet have favorable cardiac safety profiles, also evoke another effect; they increase the current amplitude upon low-voltage d...

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Literature Corpus work: 5329ac84-8b4a-5ff1-86ac-c9b2fa32e4bd
DOI: 10.1101/341875

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