Article

Reflex sympatho-vagal coactivation and concealed QTc prolongation: Lessons from hERG-blockers and long QT syndromes type 1 and type 2

2021-02-20

Abstract excerpt

<h4>Background: </h4> and Purposes: Several hERG blocking molecules known for their propensity in triggering Torsades de Pointes (TdP) were reported as increasing High Frequency QT oscillations (HFQT). This effect was found as reflecting a sympatho-vagal coactivation. The present work aims to characterise the mechanism(s) leading to this particular state of the autonomic nervous system. Experimental approach: Effe...

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Literature Corpus work: e8ddf4ea-daba-5cf9-945b-8b071220b278
DOI: 10.22541/au.161383229.97822546/v1

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