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Sex-specific amplification of <i>I</i> <sub>Kr</sub> -blocker–induced action potential prolongation by reduced female <i>I</i> <sub>Ks</sub> repolarization reserve: a computational study using the O’Hara-Rudy human ventricular model

2026-05-11

Abstract excerpt

<h4>Background</h4> Women experience drug-induced Torsades de Pointes (TdP) at approximately twice the rate of men across more than 50 QT-prolonging drug classes, yet the quantitative ionic basis of this sex disparity remains incompletely characterised. The slow delayed rectifier current ( I Ks ) is reduced by ∼45% in female compared with male human ventricular cardiomyocytes, reducing the repolarization reserve...

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Literature Corpus work
9850f735-83c3-56d7-9389-f8c817696c39
DOI
10.64898/2026.05.07.723338
Open publication

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Sex-specific amplification of <i>I</i> <sub>Kr</sub> -blocker–induced action potential prolongation by reduced female <i>I</i> <sub>Ks</sub> repolarization reserve: a computational study using the O’Hara-Rudy human ventricular modelDOI 10.64898/2026.05.07.723338
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