Article

A hERG Blocker Facilitates K <sup>+</sup> Channel Current by Agonizing Pore Opening while Blocking

2026-06-03

Abstract excerpt

Many drugs that block voltage-gated K + channels encoded by the human Ether-à-go-go-Related Gene (hERG) can cause long QT syndrome and life-threatening cardiac arrhythmias, yet the molecular mechanisms that determine this risk remain unclear. A process that may counteract arrhythmogenic hERG block, termed facilitation, is common to many clinically-approved hERG blockers including nifekalant, amiodarone, promethaz...

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Literature Corpus work: 6284d15b-7d09-5623-ad43-a2e55a3131e5
DOI: 10.64898/2026.05.30.728541

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A hERG Blocker Facilitates K <sup>+</sup> Channel Current by Agonizing Pore Opening while BlockingDOI 10.64898/2026.05.30.728541Read

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