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Article

Mutational analysis of block and facilitation of HERG current by a class III anti-arrhythmic agent, nifekalant.

Channels (Austin, Tex.) - 1 Jan 2000

Hosaka Yukio, Iwata Miki, Kamiya Narutoshi, Yamada Mitsuhiko, Kinoshita Kengo, Fukunishi Yoshifumi, Tsujimae Kenji, Hibino Hiroshi, Aizawa Yoshifusa, Inanobe Atsushi, Nakamura Haruki, Kurachi Yoshihisa

Abstract excerpt

Chemicals and toxins are useful tools to elucidate the structure-function relationship of various proteins including ion channels. The HERG channel is blocked by many compounds and this may cause life-threatening cardiac arrhythmia. Besides block, some chemicals such as the class III anti-arrhythmic agent nifekalant stimulate HERG at low potentials by shifting its activation curve towards hyperpolarizing...

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Identifiers

PMID: 18690032
DOI: 10.4161/chan.4691

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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