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Methadone blockade of I <sub>K1</sub> promotes both long QT and Brugada-like arrhythmias: Mechanistic insights from computational modeling

2025-03-07

Abstract excerpt

<h4>Background</h4> Methadone is widely used for chronic pain relief and in the maintenance therapy of opioid use disorder, however, it also increases the risk of ventricular arrhythmias and sudden cardiac death. Methadone blocks several ionic currents with different half-maximal inhibitory concentrations (IC 50 ), including the rapid component of the delayed rectifier potassium current (I Kr ), the inward rect...

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Literature Corpus work
fac06151-7423-5724-97f4-6c4d71759531
DOI
10.1101/2025.03.01.641012
Open publication

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Methadone blockade of I <sub>K1</sub> promotes both long QT and Brugada-like arrhythmias: Mechanistic insights from computational modelingDOI 10.1101/2025.03.01.641012
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