Article

The impact of uncertainty in hERG binding mechanism on <i>in silico</i> predictions of drug-induced proarrhythmic risk

2023-03-15

Abstract excerpt

<h4>Background and Purpose</h4> Drug-induced reduction of the rapid delayed rectifier potassium current carried by the human Ether-à-go-go-Related Gene (hERG) channel is associated with increased risk of arrhythmias. Recent updates to drug safety regulatory guidelines attempt to capture each drug’s hERG binding mechanism by combining in vitro assays with in silico simulations. In this study, we investigate the...

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Literature Corpus work: 6c0838b1-edcf-5cf4-b0c1-05f173460fd5
DOI: 10.1101/2023.03.14.532553

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