Inhibitory effects of cenobamate on multiple human cardiac ion channels and possible arrhythmogenic consequences

Abstract excerpt

Cenobamate is a novel third-generation antiepileptic drug used for treatment of focal onset seizures and particularly for multi-drug-resistant epilepsy, producing a reduction in monthly seizure frequency of up to 55% and unprecedented seizure-free rates of up to 28% due to action on multiple targets: GABA A receptors (EC50 42–194µM) and inhibition of persistent neuronal Na + currents (IC50 59µM). Side effects incl...

Topics

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• Action Potentials
• Arrhythmias, Cardiac
• Cell Membrane
• Ion Channel Gating
• Mutation
• Myocytes, Cardiac
• Potassium Channel Blockers
• Potassium Channels

Identifiers and source

Literature Corpus work

4c2d6c2b-6455-5135-991b-aca82ed9c9d4

DOI

10.21203/rs.3.rs-3735338/v1