Article

Facilitation by a hERG blocker is induced by pore opening and operates by pore reopening

2022-05-29

Abstract excerpt

A drug that blocks the cardiac myocyte voltage-gated K + channels encoded by the human Ether-à-go-go-Related Gene (hERG) carries a potential risk of long QT syndrome and life-threatening cardiac arrhythmia, including Torsade de Points . Interestingly, certain hERG blockers can also facilitate hERG activation to increase hERG currents, which may reduce proarrhythmic potential. However, the molecular mechanism inv...

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Identifiers and source

Literature Corpus work: 84c6f555-bc11-5149-ad82-5bbd08c4fc03
DOI: 10.1101/2022.05.26.493575

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