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Article

Inactivation gating determines drug potency: a common mechanism for drug blockade of HERG channels.

Acta pharmacologica Sinica - 1 May 2004

Yang Bao-feng, Xu Dong-hui, Xu Chao-qian, Li Zhe, Du Zhi-min, Wang Hui-zhen, Dong De-li

Abstract excerpt

AIM: To determine the mechanisms of interactions between different drugs and HERG channels. METHODS: Various antiarrhythmic (dofetilide, quinidine, azimilide, RP58866) and non-antiarrhythmic (terfenadine, nicotine) agents were used on HERG channels expressed in Xenopus oocyte. Whole-cell voltage-clamp techniques were used. RESULTS: All drugs produced concentration-dependent block of HERG current. The inhibition...

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PMID: 15132818

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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