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Article

[HERG K+ channel, the target of anti-arrhythmias drugs].

Yao xue xue bao = Acta pharmaceutica Sinica - 1 Jul 2007

Guan Feng-ying, Yang Shi-jie

Abstract excerpt

Rapidly activating component of delayed rectifier potassium current (I(Kr)) plays a key role in the repolarization phase of cardiac action potential. Human ether-a-go-go-related gene (HERG) encodes the alpha subunit of this potassium channel. Mutations of HERG gene induce genetic long QT syndrome (LQTS). Furthermore, I(Kr)/HERG is the target of some drugs which may cause cardiac QT interval prolongation. Some...

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Source

Identifiers

PMID: 17882949

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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