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Article

In silico risk assessment for drug-induction of cardiac arrhythmia.

Progress in biophysics and molecular biology - 1 Sept 2008

Suzuki Shingo, Murakami Shingo, Tsujimae Kenji, Findlay Ian, Kurachi Yoshihisa

Abstract excerpt

The main components of repolarization reserve for the ventricular action potential (AP) are the rapid (I(Kr)) and slow (I(Ks)) delayed outward K(+) currents. While many drugs block I(Kr) and cause life-threatening arrhythmias including torsades de pointes, the frequency of arrhythmias varies between different I(Kr)-blockers. Different types of block of I(Kr) cause distinct phenotypes of prolongation of action...

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Source

Identifiers

PMID: 18635251
DOI: 10.1016/j.pbiomolbio.2008.05.003

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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