Article
[Ionic mechanisms of action of class III antiarrhythmic drugs].
Kardiologiia - 1 Jan 2010
Kuz'min V S, Rozenshtraukh L V
Abstract excerpt
In this review we discuss mechanisms of antiarrhythmic and adverse proarrhythmic action of class III drugs. Special attention is given to ionic currents and channels which determine specific features of their effects (IKr, IKa, IKur). We consider general patterns of changes of bioelectrical activity in atria and ventricles leading to development of arrhythmias or stabilization of rhythm. We also discuss value of...
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