Article

Timing and clustering co-occurring genome amplifications in cancers

2025-04-03

Abstract excerpt

Clonal evolution in cancer is driven by genomic alterations that accumulate over time, shaping tumour progression, therapy resistance, and metastasis. Among these somatic events, genomic amplifications are a broad class of copy number alterations (CNAs) that can be mathematically timed (i.e., mapped to an abstract timeline). Existing methods successfully order amplifications in time but fail to understand their co...

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Literature Corpus work: 53217dd5-d101-5761-b27f-8c34663c29bf
DOI: 10.1101/2025.03.31.646456

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