Article

CNETML: Maximum likelihood inference of phylogeny from copy number profiles of spatio-temporal samples

2022-03-20

Abstract excerpt

Phylogenetic trees based on copy number alterations (CNAs) for multi-region samples of a single cancer patient are helpful to understand the spatio-temporal evolution of cancers, especially in tumours driven by chromosomal instability. Due to the high cost of deep sequencing data, low-coverage data are more accessible in practice, which only allow the calling of (relative) total copy numbers due to the lower resol...

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Literature Corpus work: cb4c4a44-c05d-55de-84e1-c2ba688c386e
DOI: 10.1101/2022.03.18.484889

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