Article

Deciphering selection patterns of somatic copy-number events

2026-03-03

Abstract excerpt

Somatic copy-number alterations (SCNAs) are pervasive across cancers, arising through diverse mutational mechanisms and subsequently shaped by selection according to fitness advantages [1–4]. These alterations can drive tumourigenesis via gene-dosage changes in oncogenes and tumour suppressors [5, 6]. However, observed SCNA profiles do not uniquely define the genomic events that led to them, which is a major obsta...

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Literature Corpus work: 963ef648-9391-5256-951a-6126b89375b0
DOI: 10.64898/2026.03.01.708809

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