Article

MEDICC2: whole-genome doubling aware copy-number phylogenies for cancer evolution

2021-02-28

Abstract excerpt

Chromosomal instability (CIN) and somatic copy-number alterations (SCNA) play a key role in the evolutionary process that shapes cancer genomes. SC-NAs comprise many classes of clinically relevant events, such as localised amplifications, gains, losses, loss-of-heterozygosity (LOH) events, and recently discovered parallel evolutionary events revealed by multi-sample phasing. These events frequently appear jointly...

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Literature Corpus work: 5e083974-578f-5129-9d81-66afa2431553
DOI: 10.1101/2021.02.28.433227

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