Article
Evolution of oncogene amplification across 86,000 cancer cell genomes
2026-02-14
Abstract excerpt
High-level copy-number (CN) amplification (HLAMP) is a major mechanism of oncogene activation in human cancer. Despite progress in therapeutically targeting amplified oncogenes, the processes underlying amplicon evolution remain incompletely understood, leaving critical knowledge gaps in their etiology and mechanisms of therapeutic response. To address this, we analyzed the evolutionary trajectories of HLAMPs usin...
Topics
Open a Topic to create a Post that cites this publication.
Identifiers and source
- Literature Corpus work
- 55801b60-291e-59be-94dd-73fc8ce1090b
- DOI
- 10.64898/2026.02.12.705658