Article

Evolving copy number gains promote tumor expansion and bolster mutational diversification

2022-06-17

Abstract excerpt

Charting the evolutionary history of rampant somatic copy number alterations (SCNA) is an indispensable step toward a deeper understanding of their roles in tumor development. However, the existing SCNA timing analysis is limited to low copy number states and initiating gains, which are not necessarily close to the onset of the malignant proliferation. Moreover, it remains a critical question if the timing of an S...

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Literature Corpus work: b366f380-05a2-5e9f-9745-48fad8242000
DOI: 10.1101/2022.06.14.495959

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