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Article

TITAN: inference of copy number architectures in clonal cell populations from tumor whole-genome sequence data.

Genome research - 1 Nov 2014

Ha Gavin, Roth Andrew, Khattra Jaswinder, Ho Julie, Yap Damian, Prentice Leah M, Melnyk Nataliya, McPherson Andrew, Bashashati Ali, Laks Emma, Biele Justina, Ding Jiarui, Le Alan, Rosner Jamie, Shumansky Karey, Marra Marco A, Gilks C Blake, Huntsman David G, McAlpine Jessica N, Aparicio Samuel, Shah Sohrab P

Abstract excerpt

The evolution of cancer genomes within a single tumor creates mixed cell populations with divergent somatic mutational landscapes. Inference of tumor subpopulations has been disproportionately focused on the assessment of somatic point mutations, whereas computational methods targeting evolutionary dynamics of copy number alterations (CNA) and loss of heterozygosity (LOH) in whole-genome sequencing data remain...

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Identifiers

PMID: 25060187
DOI: 10.1101/gr.180281.114
PMCID: PMC4216928

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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