Article

Decomposing the subclonal structure of tumors with two-way mixture models on copy number aberrations

2018-03-08

Abstract excerpt

Multistage tumorigenesis is a dynamic process characterized by the accumulation of mutations. Thus, a tumor mass is composed of genetically divergent cell subclones. With the advancement of next-generation sequencing (NGS), mathematical models have been recently developed to decompose tumor subclonal architecture from a collective genome sequencing data. Most of the methods focused on single-nucleotide variants (S...

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Literature Corpus work: 4faf5227-ca1b-57af-9a3c-13e76f2936ac
DOI: 10.1101/278887

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