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Article

Copy number evolution with weighted aberrations in cancer

1 Jul 2020

Abstract excerpt

MOTIVATION: Copy number aberrations (CNAs), which delete or amplify large contiguous segments of the genome, are a common type of somatic mutation in cancer. Copy number profiles, representing the number of copies of each region of a genome, are readily obtained from whole-genome sequencing or microarrays. However, modeling copy number evolution is a substantial challenge, because different CNAs may overlap with...

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PMID: 32657354
DOI: 10.1093/bioinformatics/btaa470

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