Article

Error-corrected Duplex Sequencing enables direct detection and quantification of mutations in human TK6 cells with remarkable inter-laboratory consistency

2023-02-22

Abstract excerpt

<h4>ABSTRACT</h4> Error-corrected Duplex Sequencing (DuplexSeq) enables direct quantification of low-frequency mutations and offers tremendous potential for chemical mutagenicity assessment. We investigated the utility of DuplexSeq to quantify induced mutation frequency (MF) and spectrum in human lymphoblastoid TK6 cells exposed to a prototypical DNA alkylating agent, N -ethyl- N -nitrosourea (ENU). Furthermore...

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Literature Corpus work: 52f13abb-68f6-5783-8977-a5e356616dbc
DOI: 10.1101/2023.02.22.529418

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