Article

Improved Mutation Detection in Duplex Sequencing Data with Sample-Specific Error Profiles

2025-07-18

Abstract excerpt

<h4>ABSTRACT</h4> Duplex sequencing enables highly accurate detection of rare somatic mutations, but existing variant callers often rely on protocol-specific heuristics that limit sensitivity, reproducibility, and cross-study comparability. We present DupCaller, a probabilistic variant caller that builds sample-specific error profiles and applies a strand-aware statistical model for mutation detection. Across 50...

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Literature Corpus work: 150995c8-ca9a-5726-a73c-1903b1ee1c5f
DOI: 10.1101/2025.07.13.664565

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