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Adopting duplex sequencing technology for genetic toxicity testing: A proof-of-concept mutagenesis experiment with N-ethyl-N-nitrosourea (ENU)-exposed rats.

Mutation research. Genetic toxicology and environmental mutagenesis - 1 Oct 2023

Smith-Roe Stephanie L, Hobbs Cheryl A, Hull Victoria, Todd Auman J, Recio Leslie, Streicker Michael A, Rivas Miriam V, Pratt Gabriel A, Lo Fang Yin, Higgins Jacob E, Schmidt Elizabeth K, Williams Lindsey N, Nachmanson Daniela, Valentine Iii Charles C, Salk Jesse J, Witt Kristine L

Abstract excerpt

Duplex sequencing (DS) is an error-corrected next-generation sequencing method in which molecular barcodes informatically link PCR-copies back to their source DNA strands, enabling computational removal of errors in consensus sequences. The resulting background of less than one artifactual mutation per 107 nucleotides allows for direct detection of somatic mutations. TwinStrand Biosciences, Inc. has developed a...

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Identifiers

PMID: 37770135
DOI: 10.1016/j.mrgentox.2023.503669
PMCID: PMC10539650

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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