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Article

Direct, genome-wide assessment of DNA mutations in single cells.

Nucleic acids research - 1 Mar 2012

Gundry Michael, Li Wenge, Maqbool Shahina Bano, Vijg Jan

Abstract excerpt

DNA mutations are the inevitable consequences of errors that arise during replication and repair of DNA damage. Because of their random and infrequent occurrence, quantification and characterization of DNA mutations in the genome of somatic cells has been difficult. Random, low-abundance mutations are currently inaccessible by standard high-throughput sequencing approaches because they cannot be distinguished...

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Identifiers

PMID: 22086961
DOI: 10.1093/nar/gkr949
PMCID: PMC3300019

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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