Transferability, Reproducibility and Sensitivity of Mutation Quantification by Duplex Sequencing.

doi:10.1002/em.70020

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Transferability, Reproducibility and Sensitivity of Mutation Quantification by Duplex Sequencing.

Environmental and molecular mutagenesis - 1 Aug 2025

Zhang Shaofei, Parsons Barbara L, Fitzgerald Devon, Ashford Anne, Auman James Todd, Chen Tao, Dodge Annette, Elhajouji Azeddine, Pfaller Lena, Harris Shawn, Higgins Jake, Hobbs Cheryl A, Marchetti Francesco, Meier Matthew J, Myers Meagan B, Salk Jesse, Sahroui Rebecca, Schuster David, Settivari Raja, Smith-Roe Stephanie L, Yauk Carole L, Yan Jian, Williams Andrew, Chen Connie L

Abstract excerpt

Duplex Sequencing (DS) is an ultra-accurate, error-corrected next generation sequencing (ecNGS) technology for mutation analysis. A working group (WG) within Health and Environmental Sciences Institute's Genetic Toxicology Technical Committee is investigating the suitability of ecNGS for regulatory mutagenicity testing, using DS as a model. Initial steps to promote acceptance require demonstrating technical...

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PMID: 40586373
DOI: 10.1002/em.70020
PMCID: PMC12451229

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