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Article

Error-corrected duplex sequencing enables direct detection and quantification of mutations in human TK6 cells with strong inter-laboratory consistency.

Mutation research. Genetic toxicology and environmental mutagenesis - 1 Jul 2023

Cho Eunnara, Swartz Carol D, Williams Andrew, V Rivas Miriam, Recio Leslie, Witt Kristine L, Schmidt Elizabeth K, Yaplee Jeffry, Smith Thomas H, Van Phu, Lo Fang Yin, Valentine Charles C, Salk Jesse J, Marchetti Francesco, Smith-Roe Stephanie L, Yauk Carole L

Abstract excerpt

Error-corrected duplex sequencing (DS) enables direct quantification of low-frequency mutations and offers tremendous potential for chemical mutagenicity assessment. We investigated the utility of DS to quantify induced mutation frequency (MF) and spectrum in human lymphoblastoid TK6 cells exposed to a prototypical DNA alkylating agent, N-ethyl-N-nitrosourea (ENU). Furthermore, we explored appropriate...

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Identifiers

PMID: 37491114
DOI: 10.1016/j.mrgentox.2023.503649
PMCID: PMC10395007

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