Article

Direct Quantification of <i>in vivo</i> Mutagenesis and Carcinogenesis Using Duplex Sequencing

2020-06-29

Abstract excerpt

<h4>ABSTRACT</h4> The ability to accurately measure mutations is critical for basic research and identification of potential drug and chemical carcinogens. Current methods for in vivo quantification of mutagenesis are limited because they rely on transgenic rodent systems that are low-throughput, expensive, prolonged, and don’t fully represent other species such as humans. Next generation sequencing (NGS) is a c...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: c873a91e-0b7a-55d5-a98a-b691921d1add
DOI: 10.1101/2020.06.28.176685

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

Direct Quantification of <i>in vivo</i> Mutagenesis and Carcinogenesis Using Duplex SequencingDOI 10.1101/2020.06.28.176685Read

Direct quantification of in vivo mutagenesis and carcinogenesis using duplex sequencing.Semantic proximity Read

Adopting Duplex Sequencing™ Technology for Genetic Toxicity Testing: A Proof-of-Concept Mutagenesis Experiment with N-Ethyl-N-Nitrosourea (ENU)-Exposed RatsSemantic proximity Read

Adopting duplex sequencing technology for genetic toxicity testing: A proof-of-concept mutagenesis experiment with N-ethyl-N-nitrosourea (ENU)-exposed rats.Semantic proximity Read

Error-corrected next generation sequencing - Promises and challenges for genotoxicity and cancer risk assessment.Semantic proximity Read

Whole-genome high-fidelity sequencing: A novel approach to detecting and characterization of mutagenicity in vivo.Semantic proximity Read

Duplex sequencing identifies unique characteristics of ENU-induced mutations in male mouse germ cells†.Semantic proximity Read

Duplex sequencing identifies genomic features that determine susceptibility to benzo(a)pyrene-induced in vivo mutations.Semantic proximity Read

Next Generation Sequencing Workshop at the Royal Society of Medicine (London, May 2022): how genomics is on the path to modernizing genetic toxicology.Semantic proximity Read

A high-throughput next-generation sequencing-based method for detecting the mutational fingerprint of carcinogens.Semantic proximity Read

High-throughput sequencing in mutation detection: A new generation of genotoxicity tests?Semantic proximity Read

Assessment of in vivo chemical mutagenesis by long-read sequencing.Semantic proximity Read

Error-corrected Duplex Sequencing enables direct detection and quantification of mutations in human TK6 cells with remarkable inter-laboratory consistencySemantic proximity Read