Article
Error-corrected next generation sequencing - Promises and challenges for genotoxicity and cancer risk assessment.
Mutation research. Reviews in mutation research - 1 Jan 2000
Marchetti Francesco, Cardoso Renato, Chen Connie L, Douglas George R, Elloway Joanne, Escobar Patricia A, Harper Tod, Heflich Robert H, Kidd Darren, Lynch Anthony M, Myers Meagan B, Parsons Barbara L, Salk Jesse J, Settivari Raja S, Smith-Roe Stephanie L, Witt Kristine L, Yauk Carole L, Young Robert, Zhang Shaofei, Minocherhomji Sheroy
Abstract excerpt
Error-corrected Next Generation Sequencing (ecNGS) is rapidly emerging as a valuable, highly sensitive and accurate method for detecting and characterizing mutations in any cell type, tissue or organism from which DNA can be isolated. Recent mutagenicity and carcinogenicity studies have used ecNGS to quantify drug-/chemical-induced mutations and mutational spectra associated with cancer risk. ecNGS has potential...
Read the complete abstract on PubMedTopics
Share this publication in a Topic to start or enrich a Post.