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Application of next-generation sequencing in the detection of low-abundance mutations.

Yi chuan = Hereditas - 20 Feb 2024

Luan Yang, You Xin-Yue, Yang Jin

Abstract excerpt

Mutation accumulation in somatic cells contributes to cancer development, aging and many non-malignant diseases. The true mutation frequency in normal cells is extremely low, which presents a challenge in detecting these mutations at such low frequencies. The emergence of next-generation sequencing (NGS) technology enables direct detection of rare mutations across the entire genome of any species. This...

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PMID: 38340003
DOI: 10.16288/j.yczz.23-309

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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