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Background Mutation Frequencies in TK6 and L5178Y Cells: Implications for Error-Corrected Sequencing.

Environmental and molecular mutagenesis - 1 Aug 2025

Miranda Jaime A, Dad Azra, Qu Xuewei, Seo Ji-Eun, Li Xilin, Guo Xiaoqing, Revollo Javier R

Abstract excerpt

Several error-corrected sequencing (ECS) methods can detect ultralow-frequency mutations and support mutagenicity assessments. While ECS can be applied to any DNA-containing sample, spontaneous mutations that accumulate in immortalized cell cultures-likely due to DNA replication errors-may elevate background mutation frequencies (MFs) and potentially confound ECS-based mutagenicity assessments. This study...

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PMID: 40663548
DOI: 10.1002/em.70024

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