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Article

Detecting Rare Mutations and DNA Damage with Sequencing-Based Methods.

Trends in biotechnology - 1 Jul 2018

Sloan Daniel B, Broz Amanda K, Sharbrough Joel, Wu Zhiqiang

Abstract excerpt

There is a great need in biomedical and genetic research to detect DNA damage and de novo mutations, but doing so is inherently challenging because of the rarity of these events. The enormous capacity of current DNA sequencing technologies has opened the door for quantifying sequence variants present at low frequencies in vivo, such as within cancerous tissues. However, these sequencing technologies are error...

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Identifiers

PMID: 29550161
DOI: 10.1016/j.tibtech.2018.02.009
PMCID: PMC6004327

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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