Article

Cohesin-mediated loop anchors confine the location of human replication origins

2021-01-06

Abstract excerpt

DNA replication occurs through an intricately regulated series of molecular events and is fundamental for genome stability across dividing cells in metazoans. It is currently unknown how the location of replication origins and the timing of their activation is determined in the human genome. Here, we dissect the role for G1 phase topologically associating domains (TADs), subTADs, and loops in the activation of rep...

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Literature Corpus work: 51f27bc6-6191-5f41-9c8c-a063fd443c46
DOI: 10.1101/2021.01.05.425437

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