Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Cell cycle-dependent TICRR/TRESLIN and MTBP chromatin binding mechanisms and patterns

7 Jul 2025

Abstract excerpt

BACKGROUND: The selection of replication origins is a defining characteristic of DNA replication in eukaryotes, yet its mechanism in humans has not been well defined. Potential DNA replication origins are licensed through the recruitment of a pair of minichromosome maintenance complexes (MCMs). In yeast, a subset of MCMs is selected for initiation by the SLD3-SLD7 firing factors during G1. Like in yeast,...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Bacterial Genetics and Biotechnology
Share to DNA Repair Mechanisms
Share to Genetic factors in colorectal cancer

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Source

Identifiers

PMID: 40624716
DOI: 10.1186/s13059-025-03665-9

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Cell cycle-dependent TICRR/TRESLIN and MTBP chromatin binding mechanisms and patternsPMID 40624716Read ↗

Cell Cycle-Dependent TICRR/TRESLIN and MTBP Chromatin Binding Mechanisms and PatternsSemantic proximity Read ↗

How MCM loading and spreading specify eukaryotic DNA replication initiation sitesSemantic proximity Read ↗

Cohesin-mediated loop anchors confine the location of human replication originsSemantic proximity Read ↗

Active transcription regulates ORC/MCM distribution whereas replication timing correlates with ORC density in human cellsSemantic proximity Read ↗

Identification of a Heteromeric Complex That Promotes DNA Replication Origin Firing in Human CellsSemantic proximity Read ↗

Chromosomal Mcm2-7 distribution is the primary driver of the genome replication program in species from yeast to humansSemantic proximity Read ↗

Human ORC/MCM density is low in active genes and correlates with replication time but does not solely define replication initiation zonesSemantic proximity Read ↗

Different nucleosomal architectures at early and late replicating origins in Saccharomyces cerevisiae.Semantic proximity Read ↗

Replication Stress, Genomic Instability, and Replication Timing: A Complex Relationship.Semantic proximity Read ↗

H3K37me1 couples transcription with DNA replication origin selectionSemantic proximity Read ↗

Integrative analysis of DNA replication origins and ORC-/MCM-binding sites in human cells reveals a lack of overlapSemantic proximity Read ↗

Most human DNA replication initiation is dispersed throughout the genome with only a minority within previously identified initiation zonesSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.