Article

Telomere-to-telomere human DNA replication timing profiles

2022-03-29

Abstract excerpt

The spatiotemporal organization of DNA replication produces a highly robust and reproducible replication timing profile. Sequencing-based methods for assaying replication timing genome-wide have become commonplace, but regions of high repeat content in the human genome have remained refractory to analysis. Here, we report the first telomere-to-telomere replication timing profiles in human, using the T2T-CHM13 geno...

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Literature Corpus work: 3c8e7c5f-2d9c-5d81-961f-9b6b69b842dd
DOI: 10.1101/2022.03.28.486072

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