Article

Nucleolus association of chromosomal domains is largely maintained in cellular senescence despite massive nuclear reorganisation

2016-05-24

Abstract excerpt

Mammalian chromosomes are organized in structural and functional domains of 0.1-10 Mb, which are characterized by high self-association frequencies in the nuclear space and different contact probabilities with nuclear sub-compartments. They exhibit distinct chromatin modification patterns, gene expression levels and replication timing. Recently, nucleolus-associated chromosomal domains (NADs) have been discovered,...

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Literature Corpus work: 6231f711-25ab-5215-9a34-6c01700edabd
DOI: 10.1101/054908

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